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Longitudinal Mutational Landscape and Transcriptomic Analysis of Aggressive Uterine Leiomyosarcoma in a Patient With Exceptional Survival
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"Longitudinal Mutational Landscape and Transcriptomic Analysis of Aggressive Uterine Leiomyosarcoma in a Patient With Exceptional Survival"

Uterine leiomyosarcoma (uLMS) is a rare aggressive sarcoma of the smooth muscle layer of the uterus manifested in high local recurrence and metastatic rate. Effective treatment of patients with uLMS is challenged by limited understanding of the molecular mechanisms driving uLMS.

In this webinar, Tatiana Omelchenko, Deep Pandya, and Jean-Noël Billaud will present a unique case study of a treatment-naive patient with aggressive metastatic uLMS and multiple pulmonary metastases who has experienced long-term survival for more than seven years without therapy except for surgery. Using whole-exome sequencing, the speakers analyzed five tumors — one primary and four lung metastases — for shared and unique mutational and transcriptional expression signatures to explore and identify mechanisms of uLMS tumor growth and metastasis in this patient.

Attendees of this webinar will learn:

Which mutations and pathways were identified as potential regulators of tumor growth in the patient

How a combination of variant analysis and transcriptomic analysis enabled the identification of potential drivers of metastatic processes and which bioinformatics tools were used

What mechanisms and targeted therapy strategies the speakers proposed for this uLMS patient and how these recommendations apply to other sarcomas with specific genomic alterations


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