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Leveraging the Power of High-Parameter Cell Sorting and Single-Cell Multiomics to Profile Intratumoral Immune Cells in a Model of B-Cell Lymphoma
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"Leveraging the Power of High-Parameter Cell Sorting and Single-Cell Multiomics to Profile Intratumoral Immune Cells in a Model of B-Cell Lymphoma"

This white paper from BD Life Sciences examines a murine model of B-cell lymphoma with a focus on the function of the B- and T-lymphocyte attenuator (BTLA) in the progression of the tumor.

To investigate cell composition in the lymphoma microenvironment, the researchers designed a high-throughput sorting strategy to enable concurrent isolation of six cell populations from the tumor niche using the BD FACSymphony S6 Cell Sorter. Then, downstream application of a single-cell multiomic approach was used for a robust characterization of the sorted cell populations. The analyses revealed that the loss of BTLA function may increase the proportions of CD8⁺ T cells that express CD279 as a response to the onset of B-cell lymphoma in a mouse model.


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