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"Keeping the Promise of Immuno-Oncology With Simple Western and Single-Cell Western"

Immuno-oncology has created revolutionary therapies for some, but the full promise of immuno-oncology has yet to be realized.

Among the top approaches for immunotherapies are altering the tumor microenvironment to prevent immunosuppression, blocking immune checkpoint inhibitors, and reprogramming immune cells to target antigens presented on cancer cells. Despite the diversity of these approaches, a commonality is a need for protein analytical methods that preserve precious samples, while also providing assay robustness in terms of sensitivity, reproducibility, and quantification.

To realize the full potential of immuno-oncology, ProteinSimple, a Bio-Techne brand, provides next-generation protein analytical tools to uncover the role of proteins in cancer and provide novel approaches to develop and analyze protein-based therapeutics. Simple Western is a capillary-based automated immunoassay for the characterization of proteins in complex mixtures. Unlike traditional western blot, which is time-consuming and often irreproducible, Simple Western provides highly quantitative and reproducible protein expression data in a fraction of the time (as little as three hours). Single-Cell Westerns on Milo perform western analysis on ~1,000 individual cells at a time, providing unparalleled insight into population heterogeneity.

This application note from Bio-Techne shows how Simple Western and Single-Cell Western can contribute to three important branches of immuno-oncology: angiogenesis of the tumor microenvironment, immune checkpoint inhibition, and chimeric antigen T-cell (CAR T-cell) therapy.

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