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Investigating Cell-Free DNA in Liquid Biopsy
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"Investigating Cell-Free DNA in Liquid Biopsy"

Liquid biopsy is a revolutionary approach that is opening previously unexpected opportunities in oncology. It empowers the detection and isolation of circulating tumor cells, cell-free DNA, and circulating tumor DNA, drawing on the strength of NGS technologies now available.

Many difficulties have been overcome, but there is still no standardized approach for liquid biopsy processing and cell-free DNA analysis. Substantial progress has been made regarding sample preparation and isolation. However, continued progress in reducing genomic DNA contamination and PCR inhibitors is needed to further improve sensitivity.

This white paper from Cytiva discusses the challenges and opportunities in measuring the small amount of cell-free DNA in liquid samples for applications including oncology, organ and transplant medicine, and non-invasive prenatal testing.


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