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Introducing a Novel Chromogenic ISH Assay for High-Resolution Detection of DNA Copy Number and Structural Variants
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"Introducing a Novel Chromogenic ISH Assay for High-Resolution Detection of DNA Copy Number and Structural Variants"

Genomic DNA anomalies are important biomarkers and drug targets in many cancer types.

DNA in-situ hybridization (ISH) is the standard method to directly visualize these molecular alterations, but currently available fluorescent ISH (FISH) assays provide limited morphological detail due to the use of fluorescent nuclear staining as compared to chromogenic staining. Furthermore, FISH techniques rely on fluorescence microscopes, risk the loss of fluorescent signal over time, and involve imaging at high magnifications. There is thus an unmet need for a sensitive and robust chromogenic DNA ISH assay that can enable high-resolution detection of genomic DNA targets with the ease of bright-field microscopy.

This on-demand webinar from ACD demonstrates how the DNAscope assay can detect DNA copy number and structural variations with high specificity and enables greater morphological detail, higher resolution, and simpler interpretation than traditional DNA ISH assays without the need for specialized equipment. The DNAscope chromogenic duplex (red/blue) staining allows researchers to use a standard bright-field microscope to visualize and quantify gene copy number and structural variations in tissues with spatial and morphological context at single-cell resolution.


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