As LC-MS proteomic analysis moves from discovery to the clinic, there is an increasing need for high-throughput automation in sample prep workflows.
This white paper from Biotech Support Group describes new methods combining technologies to incorporate beads for the depletion of highly abundant blood proteins into pipette tips known as XTR tips. The XTR tip format improves ease of use and scalability to process multiple samples in parallel, utilizing 96-well plates and automated liquid handlers. The incorporated beads are consumable, and not derived from immuno-affinity. The beads are loosely contained inside the XTR tips for a dispersive functionality that maximizes depletion efficacy. Thus, this combination of technologies achieves fast, streamlined workflows that simply and robustly increase efficiencies necessary for clinical proteomic analysis of whole blood, serum, and plasma.
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