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3D cell models are often a better representation of the in vivo environment than traditional 2D methodologies. Accordingly, spheroid and other 3D models are increasingly being used for drug discovery

A high throughput system is essential to meet the 3D cell screening and 3D cell culture demands of most large-scale drug discovery programs.

An automated method has been established for seeding, dosing and assaying spheroids in Corning 1536-well spheroid microplates using INTEGRA Biosciences’ VIAFILL reagent dispenser and VIAFLO 384 handheld electronic pipette. With a maximum volume of 14 μl per well, accurate liquid handling is essential for the generation of quality data. The method was proven to generate robust, high quality data for assay development and high throughput screenings.

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