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Harnessing the Power of Lyophilization to Build Next-Generation Point-of-Care Molecular Diagnostic Tests

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"Harnessing the Power of Lyophilization to Build Next-Generation Point-of-Care Molecular Diagnostic Tests"

In the post-pandemic world, cold-chain shipment of diagnostic products is frequently disrupted, and it is often that lab users receive items that might be compromised during transportation.

Lyophilization is a simple way to extend the benefits of molecular diagnostic assays while also reducing shipping and storage costs. It is an especially valuable feature for point-of-care test kits where storage and shipping limitations may exist. It’s also beneficial for testing in remote locations where shipping delays or logistics restraints could compromise test efficacy.

This talk features Singapore-based biotech BioAcumen Global, which has developed the first ISO 13485 lyophilization manufacturing facility in the region dedicated to PCR assays that can be transported at room temperature. Applications include but are not limited to human infectious diseases and animal diagnostic detection which are used in a wide variety of settings throughout the world.

The talk showcases a recent study done by LGC Biosearch Technologies and BioAcumen Global which demonstrates the strong performance of lyophilized reagents compared to freshly mixed reagents in a 1-step real-time PCR assay. Technical considerations when developing a lyophilized assay will also be shared as the optimization could be different compared to a conventional wet version of the same assay.

Learning Points:

  • Why lyophilization is highly sought-after post-pandemic for molecular diagnostic development.
  • Key considerations for success when translating a wet version of molecular diagnostic assays to a lyophilized version.
  • Lessons from the pandemic to boost capabilities in molecular diagnostics development to be more resilient for the next disease X.

Offered Free by: LGC Biosearch Technologies
See All Resources from: LGC Biosearch Technologies

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