Traditionally chromatin conformation capture methods like Hi-C have required a minimum of 1 million cells to obtain high-resolution genome topology, which has restricted the use of certain sample types or the use of rare samples.
Recently, Dovetail Genomics released the Omni-C Kit, a modification of the company’s Hi-C approach that replaces restriction enzymes with a sequence-independent endonuclease. There is a low-input protocol for this kit that enables as few as 100,000 cells to be interrogated with minimal changes to the workflow.
This application note describes work to reduce this input significantly further and demonstrates the use of the Omni-C Kit with ultra-low input cell counts down to 1,000 cells.
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