Gene expression profiling is a powerful tool that can be used to evaluate potential drug candidates in preclinical in vivo experiments. The first step in any gene expression profiling experiment is RNA isolation and quality assessment. Formalin-fixed paraffin-embedded (FFPE) samples pose a particular challenge to gene expression profiling since these samples usually contain a high amount of fragmented RNA.
This white paper from Canopy Biosciences answers questions about gene expression profiling and RNA isolation from fresh-frozen and FFPE tissues, and it discusses how the NanoString nCounter platform does not require amplification, a necessary step for many gene profiling assays, making it ideal for targeted gene profiling from FFPE samples.
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