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Electrochemical Detection of Nucleic Acids
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"Electrochemical Detection of Nucleic Acids"

Electrochemical probes are comprised of an oligonucleotide modified with a redox reporter on one terminus and an electrode surface at the other.

Upon hybridization of a target to a redox reporter, a change in the electrochemical response of the reporter can be measured and used to detect the target. This format has been used for the detection of single-base mismatches, DNA methylation, important analytes, abasic sites, and DNA damage.1

Download this note for an introductory overview on electrochemical probes:

  • Background on electrochemically active labels
  • Oligonucleotide modifications for electrochemical labeling
  • Research application of apatamer-based biosensor development


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