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Discovering Multiple Pathways to Drug Resistance in Melanoma Cells with Single-Cell Proteomics and Single-Cell Metabolomics
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"Discovering Multiple Pathways to Drug Resistance in Melanoma Cells with Single-Cell Proteomics and Single-Cell Metabolomics"

Cancer cells constantly evolve in response to acute and chronic stimuli.

Drug resistance is one product of this evolution, as cells quickly adopt drug-resistant states when exposed to pharmacological treatments.

How cancer cells reach drug resistance remains unclear, so researchers from the California Institute for Technology implemented a multi-omics approach for characterizing drug resistance mechanisms using IsoPlexis’ single-cell intracellular proteomics and metabolomics.

Download this research summary to find out how the CalTech team used predictive single-cell functional proteomic and metabolic assays to investigate changing cellular states in melanoma cells for the development of improved targeted therapies.


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