The detection of a rare allele or mutant sequence lost in a dense background of wild type sequences is a challenge in both research and diagnostic applications of molecular biology. This situation is often encountered in oncology when trying to detect tumor-derived mutant sequences, present in very small amounts in liquid biopsies.
This video from Stilla describes the principles behind digital PCR and the technology’s advantages over traditional bulk qPCR, focusing on liquid biopsy to detect tumor-derived DNA as an example.
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