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Development of Seraseq ctDNA Myeloid Mutation Mix: A Reference Material to Monitor Sensitivity and Specificity of NGS-Based Testing in Myeloid Blood Cancers
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"Development of Seraseq ctDNA Myeloid Mutation Mix: A Reference Material to Monitor Sensitivity and Specificity of NGS-Based Testing in Myeloid Blood Cancers"

Myeloid malignancies are characterized by excessive proliferation, abnormal self-renewal, and differentiation defects of hematopoietic stem cells and myeloid progenitor cells. The detection of these types of malignancies using traditional procedures by obtaining bone marrow samples is invasive and risky. Hence, liquid biopsy-based methods are in high demand to monitor and detect new cases of blood cancer.

This poster from LGC SeraCare summarizes the development of ctDNA myeloid reference materials — a purified mix of 25 myeloid DNA variants that were blended against a wild-type background — for the development, validation, and clinical application of targeted NGS assays as well as digital PCR-based assays that analyze for myeloid diseases in cancer patients.


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