Cancer begins with mutations in the DNA of a single cell. These mutations are often caused by single nucleotide variants (SNVs) and gene copy number variants (CNVs). Differences in SNVs and CNVs contribute to cancer heterogeneity, making some clonal populations more virulent and drug-resistant than others. Accurately defining clonal populations and reconstructing clonal phylogenies can only be achieved through single-cell analysis and is critical for informed clinical research.
This application note describes a study demonstrating the ability of the Tapestri Platform to detect CNVs and SNVs simultaneously in single cells from cancer cell lines.
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