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Comprehensive Genomic Profiling: Lowering Barriers to Implementation and Access
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"Comprehensive Genomic Profiling: Lowering Barriers to Implementation and Access"

As precision treatments for cancer expand and guidelines change to recommend new biomarker tests for patients, comprehensive genomic profiling (CGP) assays -- NGS-based tests that assess a broad array of cancer biomarkers -- can provide several advantages over smaller hotspot or single-marker tests and inform treatment plans that can be quickly adapted in response to new therapies and recommendations.

As kits and services become more widely available, CGP testing rates are increasing, with some health systems offering NGS profiling to all late-stage cancer patients.

However, not all cancer patients have access to biomarker tests. Moreover, outcomes do not always improve for patients who are tested, possibly due to delays in appropriate testing or targeted treatment. These issues are due, in part, to challenges in the implementation and operationalization of NGS testing, according to some experts. Complex pre-analytical steps, challenges in test interpretation, inconsistent payor coverage, social disparities in care, long turnaround times, and other issues can sometimes stand between patients and appropriate testing or treatment. Thus, several groups are working to identify and improve implementation and workflow challenges to close the gap between what is technologically possible and the current reality for patients.

This GenomeWeb e-book, sponsored by Roche, draws on Precision Oncology News reporting to summarize the advantages of comprehensive genomic profiling, implementation and workflow hurdles that slow broad implementation, and ongoing efforts to identify and address those challenges.

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