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Circulating Protein Biomarkers are a Promising Avenue for Predicting Patient Response to Cancer Immunotherapies
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"Circulating Protein Biomarkers are a Promising Avenue for Predicting Patient Response to Cancer Immunotherapies"

Cancer immunotherapy has taken a central position in cancer treatment modalities, but not all patients respond, and combination immunotherapies increase the cost of treatment and heighten the risk for toxicity-related adverse events.

An understanding of the molecular factors that contribute to clinical outcomes could enable improved selection of subject cohorts, so identifying predictive biomarkers of immunotherapy response has become a growing focus of immuno-oncology research. Circulating protein biomarkers are of particular interest, but have been more difficult to measure due to the low concentration of biomarkers relative to unrelated background proteins and the low throughput of traditional protein detection techniques such as mass spectrometry and ELISA assays.

This white paper from SomaLogic describes the challenges of using circulating proteins as biomarkers of immunotherapy response and demonstrates the potential of the SomaScan Proteomic Platform to pinpoint mechanisms of action for immuno-oncology treatment modalities that could help identify new treatment strategies or predict response.


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