Immunology and infectious disease researchers continue to advance our understanding of significant health issues including cancer, autoimmune diseases, and emerging pathogens. However, their efforts face significant challenges due to the complex, dynamic, and heterogeneous nature of the immune system and the limitations of prevailing research tools.
To more accurately characterize cellular identity, state, and function, and to define novel cell subtypes in healthy or diseased models, it is important to measure multiple cellular readouts. The Chromium Single Cell Immune Profiling and Gene Expression Solutions with Feature Barcoding technology enable a multiomic approach by labeling cell surface proteins with DNA barcode conjugated antibodies, instead of traditional fluorophore conjugated antibodies, and integrating measurements of cell surface proteins and transcriptomes into a single readout.
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