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This application note from Glen Research presents three use cases for trimer phosphoramidites -- trinucleotide reagents used to synthesize oligonucleotides based on amino acid codons rather than individual nucleotides -- which allow researchers to create defined sequence libraries while avoiding stop codons and amino acid redundancy.

Cases include a screening method for protein affinity agents developed by the Regan Group at Yale University, an investigation of antibody regions by the Sidhu Group at the University of Toronto, and a description of a directed evolution method called compartmentalized partnered replication by the Ellington Group at the University of Texas at Austin.

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