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A Multi-Laboratory Investigation of 18 Oncogenic RNA Fusions in FFPE and Purified RNA-based Reference Materials
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"A Multi-Laboratory Investigation of 18 Oncogenic RNA Fusions in FFPE and Purified RNA-based Reference Materials"

Gene fusions, usually the result of chromosomal rearrangements, are frequently associated with many cancer types, and hence clinically actionable, making fusion detection an important part of cancer disease management.

We developed a new version of the Seraseq® Fusion RNA v4 standards, in both purified and FFPE formats, that include more common fusions of ALK, RET, and ROS1, as well as rare fusion events such as PAX-PPARG and ETV6-NTRK3. In addition, two new fusions were added on top of those found in earlier versions of the products: CCDC6-RET and TFG-NTRK1. Performance was demonstrated across several extraction kits as well as between digital PCR and various NGS enrichment assays in a multi-lab investigation.


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