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A Comprehensive Characterization of Regulatory T Cells Using BD Rhapsody Single-Cell Analysis System
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"A Comprehensive Characterization of Regulatory T Cells Using BD Rhapsody Single-Cell Analysis System"

Regulatory T cells (Tregs) play an essential role in maintaining immune homeostasis and their alterations can have many im¬plications, including tumor progression or onset of autoimmune diseases. Tregs are not a functionally homogenous population and can be subgrouped based on the expression of CD45RA and HLA-DR as naive or activated Tregs, respectively.

The use of either high-parameter protein analysis or single-cell RNA sequencing has further revealed additional subgroups representative of intermediate states of Treg differentiation. The advent of single-cell multiomic technologies offers the unprecedented ability to perform an even deeper cell characterization by integrating analysis of mRNA and proteins from the same individual cells.

This white paper from BD Life Sciences presents a study that utilized BD Rhapsody Human Immune Response Panel and BD AbSeq to dissect Treg subsets and identify putative cell differentiation trajectories, demonstrating the sensitivity and specificity of BD AbSeq for the identification of Treg subsets based on known surface marker signatures.


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