Full-Length RNA-Seq: A Novel Method to Assess Sequence Integrity for RNA Therapeutics Free Technical Brief

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"Full-Length RNA-Seq: A Novel Method to Assess Sequence Integrity for RNA Therapeutics"

Free Technical Brief: "Full-Length RNA-Seq: A Novel Method to Assess Sequence Integrity for RNA Therapeutics"

This technical note highlights the challenges faced in quality control for RNA therapeutics, an emerging area of gene therapy. Traditional methods, such as RT-PCR and RT-qPCR, have limitations when detecting poly(A) tail length and can introduce artifacts, preventing accurate and precise quantitation. An ideal quality control approach should allow for a comprehensive evaluation of full-length products, intermediates, and byproducts.
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